Published data on the methods of preparation of pyrazolopyrazoles are summarized and described systematically. The title compounds are subdivided according to the position of fusion between the 2 pyrazole rings. In addition, pyrazolo[3,4-c]pyrazoles are useful for the treatment of esophageal and gastrointestinal mucosa injury9 and brain injury, 10 and also as immunostimulatory, 11 antianginal, 12 and antitumor13 agents. A review covering the literature data on the synthesis of compounds with 2 or more pyrazole rings linked to each other published before 1995 appeared in 1995. |
