Simple and accurate spectrophotometric methods are presented for the determination of five 3-hydroxy-3- methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors (statins), namely atorvastatin, fluvastatin, pitavastatin, rosuvastatin, and simvastatin, in pharmaceutical preparations. The methods are based on the reaction of drugs as n-electron donor with 7,7,8,8-tetracyanoquinodimethane as π-acceptors to give highly colored complex species. All variables were studied in order to optimize the reaction conditions. |
