An efficient 2-component synthesis of a series of 3-(2-(substituted phenylamino)thiazol-4-yl)-2H -chromen-2- ones (3a–j) was achieved by the reaction of 3-(2-thiocyanatoacetyl)-2H -chromen-2-one (1) with a variety of suitably substituted anilines in 1:1 molar ratio in ethanol. The structures of the products were established by elemental analyses, and UV-vis, FTIR, 1H and 13C NMR, and mass spectroscopy. 3-(2-(4-Methylphenylamino)thiazol-4-yl)-2 H -chromen-2- one (3j) was further characterized by single crystal X-ray diffraction study. |
