Palladium-catalyzed Heck coupling reactions of styrene with bromoarene derivatives are carried out under aerobic conditions in water using water-soluble N,N,N′,N′-tetrakis(2-hydroxyethyl)ethylenediamine (EdteH4) and ethylenediaminetetraacetic acid disodium salt (Na2EDTA) as ligands. The effect of different bases, catalyst loading, and additives is also monitored. |