A small library of new azomethine derivatives of 3-aryl-2-thioxo-2,3-dihydroquinazolin-4(1 H) -ones was synthesized. The key intermediates 2-thioxo-quinazolinones (3a–e), obtained in 2 steps from the corresponding anilines, were treated with methyl chloroacetate to afford S-substituted esters (4a,d), which were then converted into corresponding acetohydrazides (5a,d). Further, acetohydrazide (5d) was converted to the azomethines derivatives (6a–k) by reacting with a number of suitably substituted benzaldehydes. |
