The sensitivity of the medulla spinalis to ischemia and reperfusion has been shown in previous in vitro and in vivo studies. However, less is known about the effects of carvacrol administration following ischemia and reperfusion. It was hypothesized that carvacrol might have protective effects on motor neuron functionunder ischemia- and reperfusion-induced oxidative stress. A total of 24 adult Wistar rats were divided into three groups: group I (control group; n = 8), group II (spinal ischemia and reperfusion group; n = 8), and group III (spinal ischemia and reperfusion + carvacrol group; n = 8). Ischemia and reperfusion were performed by clamping the abdominal aorta for 45 min. |
