It is of great urgency to explore useful prognostic markers for patients with clear cell renal cell carcinoma (ccRCC). Prognostic models based on ferroptosis-related gene (FRG) in ccRCC is poorly reported for now. | Chen et al. BMC Cancer 2022 22 1 https s12885-021-09033-7 RESEARCH Open Access A novel ferroptosis-related gene signature associated with cell cycle for prognosis prediction in patients with clear cell renal cell carcinoma Siteng Chen1 Encheng Zhang1 Tuanjie Guo1 Jialiang Shao1 Tao Wang1 Ning Zhang2 Xiang Wang1 and Junhua Zheng1 Abstract Background It is of great urgency to explore useful prognostic markers for patients with clear cell renal cell carci- noma ccRCC . Prognostic models based on ferroptosis-related gene FRG in ccRCC is poorly reported for now. Methods Comprehensive analysis of 22 FRGs were performed in 629 ccRCC samples from two independent patient cohorts. We carried out least absolute shrinkage and selection operator analysis to screen out prognosis-related FRGs and constructed prognosis model for patients with ccRCC. Weighted gene co-expression network analysis was also carried out for potential functional enrichment analysis. Results Based on the TCGA cohort a total of 11 prognosis-associated FRGs were selected for the construction of the prognosis model. Significantly differential overall survival hazard ratio 95 CI p Chen et al. BMC Cancer 2022 22 1 Page 2 of 11 malignant cases in renal 3 . As one of the most aggres- of iron-dependent lipid hydroperoxides 6 . Current sive malignancies ccRCC is responsible for most of the studies have also reported the important role of ferrop- death cases caused by renal tumor 4 . Even for local- tosis-related gene FRG in ccRCC. Through facilitat- ized cases about 25 of patients with ccRCC could ing ferroptosis SUV39H1 deficiency could restrain cell also be troubled by tumor recurrence after receiving growth of ccRCC in vitro and in vivo 7 . Reduced expres- operative treatment 5 . Tumor staging system is cur- sion of NCOA4 which is one of the FRG was reported to rently the most fashionable method for survival pre- be associated with tumor progression and poor prognosis diction of
