The ratio of serum apolipoprotein B (apoB) to apolipoprotein A-I (apoAI) had been reported as a prog‑ nostic factor in colorectal cancer. This retrospective study aimed to assess the implication of apoB-to-apoAI ratio in predicting liver metastasis from rectal cancer (RC). | Chen et al. BMC Cancer 2022 22 7 https s12885-021-09101-y RESEARCH Open Access Serum apolipoprotein B to apolipoprotein A-I ratio is an independent predictor of liver metastasis from locally advanced rectal cancer in patients receiving neoadjuvant chemoradiotherapy plus surgery Chen Chen1 2 Wei Yi3 Zhi fan Zeng1 2 Qiao xuan Wang1 2 Wu Jiang2 4 Yuan hong Gao1 2 and Hui Chang1 2 Abstract Background The ratio of serum apolipoprotein B apoB to apolipoprotein A-I apoAI had been reported as a prog nostic factor in colorectal cancer. This retrospective study aimed to assess the implication of apoB-to-apoAI ratio in predicting liver metastasis from rectal cancer RC . Methods The clinical data of 599 locally advanced RC patients treated with chemoradiotherapy followed by surgery were reviewed. Serum apoAI apoB and apoB-to-apoAI ratio were analyzed for their correlation with the liver-metasta sis-free other-metastasis-free and overall survivals together with the pretreatment and postsurgical pathoclinical fea tures of the patients. Univariate and multivariate survival analyses were realized through the Kaplan-Meier approach and Cox model respectively. Hazard ratios HRs and 95 confidence intervals CIs were calculated for independent predictors. Results Carbohydrate antigen 19 9 U ml apoB-to-apoAI ratio tumor regression grade 5 3 pT4 and pN stage emerged as independent predictors of poorer liver-metastasis-free survival. The hazard ratios were 95 CI 95 CI 95 CI 95 CI and 95 CI respectively. Except apoB-to-apoAI ratio the other 4 factors were also independent predictors of poorer other-metastasis-free and overall survivals. And the independent predictors of poorer overall survival also included age 67 years old distance to anal verge Chen et al. BMC Cancer 2022 22 7 Page 2 of 8 time of merely months. Yet the figure could rise to monoclonal antibody iv .
