Several studies have demonstrated that the preoperative Glasgow prognostic score (GPS) and modifed GPS (mGPS) refected the prognosis in patients undergoing curative surgery for colorectal cancer. However, there are no reports on long-term prognosis prediction using high-sensitivity mGPS (HS-GPS) in colorectal cancer. Therefore, this study aimed to calculate the prognostic value of preoperative HS-GPS in patients with colon cancer. | Kasahara et al. BMC Cancer 2022 22 20 https s12885-021-09113-8 RESEARCH Open Access Prognostic value of preoperative high- sensitivity modified Glasgow prognostic score in advanced colon cancer a retrospective observational study Kenta Kasahara Masanobu Enomoto Ryutaro Udo Tomoya Tago Junichi Mazaki Tetsuo Ishizaki Tesshi Yamada Yuichi Nagakawa Kenji Katsumata and Akihiko Tsuchida Abstract Background Several studies have demonstrated that the preoperative Glasgow prognostic score GPS and modi- fied GPS mGPS reflected the prognosis in patients undergoing curative surgery for colorectal cancer. However there are no reports on long-term prognosis prediction using high-sensitivity mGPS HS-GPS in colorectal cancer. Therefore this study aimed to calculate the prognostic value of preoperative HS-GPS in patients with colon cancer. Methods A cohort of 595 patients with advanced resectable colon cancer managed at our institution was analysed retrospectively. HS-GPS GPS and mGPS were evaluated for their ability to predict prognosis based on overall survival OS and recurrence-free survival RFS . Results In the univariate analysis HS-GPS was able to predict the prognosis with significant differences in OS but was not superior in assessing RFS. In the multivariate analysis of the HS-GPS model age pT pN and HS-GPS of 2 compared to HS-GPS of 0 2 vs 0 hazard ratio HR 95 confidence interval CI P were identified as independent prognostic predictors of OS. In the multivariate analysis of the GPS model GPS 2 vs 0 HR 95 CI P and GPS 2 vs 1 HR 95 CI P and in that of the mGPS model mGPS 2 vs 0 HR 95 CI P were independent prognostic predictors of OS. In each classification GPS outperformed HS-GPS in predicting OS with a significant difference in the area under the receiver operating characteristic curve. In the multivariate analysis of the GPS model GPS 2 vs 0 HR 95 CI .
