Adult sporadic Burkitt lymphoma (BL) is a rare but highly aggressive subtype of lymphoma which lacks its own unique prognostic model. Systemic inflammatory biomarkers have been confirmed as prognostic markers in several types of malignancy. Our objective was to explore the predictive value of pretreatment inflammatory biomarkers and establish a novel, clinically applicable prognostic index for adult patients with sporadic BL. | Chen et al. BMC Cancer 2022 22 45 https s12885-021-09144-1 RESEARCH Open Access A novel prognostic index for sporadic Burkitt lymphoma in adult patients a real-word multicenter study Mei ting Chen1 Fei Pan1 Yung chang Chen2 Wei Zhang2 Hui juan Lv3 Zhao Wang1 Huang ming Hong2 Xiao jie Fang1 Ya wen Wang4 Tao Pan5 Li qun Zou6 Hong qiang Guo7 Ke Xie8 Li min Chen1 Xiao qian Li1 Yu yi Yao1 Ze geng Chen1 Hua wei Weng1 Xu dong Li2 Yuan yuan Shen2 Hui Zhou5 Hong wei Xue4 Hui lai Zhang3 He Huang1 and Tong yu Lin1 2 Abstract Background Adult sporadic Burkitt lymphoma BL is a rare but highly aggressive subtype of lymphoma which lacks its own unique prognostic model. Systemic inflammatory biomarkers have been confirmed as prognostic markers in several types of malignancy. Our objective was to explore the predictive value of pretreatment inflammatory biomark ers and establish a novel clinically applicable prognostic index for adult patients with sporadic BL. Methods We surveyed retrospectively 336 adult patients with newly diagnosed sporadic BL at 8 Chinese medical centers and divided into training cohort n 229 and validation cohort n 107 . The pretreatment inflammatory biomarkers were calculated for optimal cut-off value. The association between serum biomarkers and overall survival OS was analyzed by Kaplan Meier curves and Cox proportional models. The risk stratification was defined based on normal LDH level Ann Arbor stage of I and completely resected abdominal lesion or single extra-abdominal mass Chen et al. BMC Cancer 2022 22 45 Page 2 of 11 associated with malaria and Epstein-Barr virus EBV 4 . training cohort. Eligible patients had histologically con- The immunodeficiency-related variant has close relation- firmed sporadic BL according to the 2008 World Health ship with human immunodeficiency virus HIV 5 . Spo- Organization WHO criteria and complete clinical lab- radic BL is typically seen in young patients but accounts oratory and follow-up data. All .
