Administration of poly (ADP-ribose) polymerase (PARP) inhibitors after achieving a response to platinum-containing drugs significantly prolonged relapse-free survival compared to placebo administration. PARP inhibitors have been used in clinical practice. However, patients with platinum-resistant relapsed ovarian cancer still have a poor prognosis and there is an unmet need. | Sato et al. BMC Cancer 2022 22 59 https s12885-021-09148-x RESEARCH Open Access Clinical significance of metabolism-related genes and FAK activity in ovarian high-grade serous carcinoma Masakazu Sato Sho Sato Daisuke Shintani Mieko Hanaoka Aiko Ogasawara Maiko Miwa Akira Yabuno Akira Kurosaki Hiroyuki Yoshida Keiichi Fujiwara and Kosei Hasegawa Abstract Background Administration of poly ADP-ribose polymerase PARP inhibitors after achieving a response to platinum-containing drugs significantly prolonged relapse-free survival compared to placebo administration. PARP inhibitors have been used in clinical practice. However patients with platinum-resistant relapsed ovarian cancer still have a poor prognosis and there is an unmet need. The purpose of this study was to examine the clinical significance of metabolic genes and focal adhesion kinase FAK activity in advanced ovarian high-grade serous carcinoma HGSC . Methods The RNA sequencing RNA-seq data and clinical data of HGSC patients were obtained from the Genomic Data Commons GDC Data Portal and analysed https portal. gdc. cancer. gov . In addition tumour tissue was sampled by laparotomy or screening laparoscopy prior to treatment initiation from patients diagnosed with stage IIIC ovarian cancer International Federation of Gynecology and Obstetrics FIGO classification 2014 at the Saitama Medical University International Medical Center and among the patients diagnosed with HGSC 16 cases of available cryopreserved specimens were included in this study. The present study was reviewed and approved by the Institu- tional Review Board of Saitama Medical University International Medical Center Saitama Japan . Among the 6307 variable genes detected in both The Cancer Genome Atlas-Ovarian TCGA-OV data and clinical specimen data 35 genes related to metabolism and FAK activity were applied. RNA-seq data were analysed using the Subio Platform Subio Inc Japan . JMP 15 SAS USA was used for statistical analysis and
