To observe the clinicopathological and prognostic value of long non-coding RNA five prime to X inactive specific transcript (lncFTX) in multiple tumors. Methods: Eligible studies for lncFTX were identified by searching PubMed, Embase, Web of Science and Cochrane Library databases from inception to December 01, 2020. Stata software was used to calculate the odds ratio (OR)/ hazard ratio (HR) and 95% confidence interval (95% CI). | Zhou et al. BMC Cancer 2022 22 61 https s12885-021-09161-0 RESEARCH Open Access Prognostic significance of long non-coding RNA five prime to XIST in various cancers Jian Zhou1 Junjie Chen2 Ziyuan Chen3 Gen Wu1 Zhen Zhou4 Tong Wu5 Wanchun Wang1 Yingquan Luo6 and Tang Liu1 Abstract Background To observe the clinicopathological and prognostic value of long non-coding RNA five prime to X inac- tive specific transcript lncFTX in multiple tumors. Methods Eligible studies for lncFTX were identified by searching PubMed Embase Web of Science and Cochrane Library databases from inception to December 01 2020. Stata software was used to calculate the odds ratio OR hazard ratio HR and 95 confidence interval 95 CI . We used The Cancer Genome Atlas TCGA dataset to further investigate the differential expression and prognostic value of lncFTX. Results We included 11 studies involving a total of 1633 patients. The results showed that the expression of lncFTX was positively associated with advanced TNM stage III-IV versus I-II OR 95 CI P Zhou et al. BMC Cancer 2022 22 61 Page 2 of 11 death 2 3 Therefore there is an urgent need to find Inclusion and exclusion criteria biomarkers that can help clinicians diagnose and treat Studies that met the following inclusion and exclusion cancers at an early stage 4 6 . criteria were eligible for this meta-analysis. Long non-coding RNA five prime to X inactive spe- cific transcript LncRNA refers to a type of non-coding RNA with a molecular length of more than 200 nucleo- Inclusion criteria tides. Recent studies showed that LncRNA may play an important role in regulating a variety of diseases 7 9 . 1 Studies with the aim of assessing clinical-patholog- Some long-chain non-coding RNAs were found that ical or prognostic significance of lncFTX in human increased significantly in tumor tissues. These data sug- cancers. gest that the LncRNA may be used as a biomarker for 2 Patients were categorized into two groups .
