Activated Cdc42-associated kinase 1 (ACK1), a kind of tyrosine kinase, is considered to be an oncogene in many cancers, and it is likely to become a potential target for cancer treatment. We found that the expression of the ACK1 gene in colon cancer was higher than that in normal tissues adjacent to cancer, and high expression of the ACK1 gene was associated with poor prognosis of patients. | Kong et al. BMC Cancer 2022 22 84 https s12885-021-09165-w RESEARCH Open Access Identification of an ACK1 TNK2-based prognostic signature for colon cancer to predict survival and inflammatory landscapes Defeng Kong1 Guoliang Li1 Zhenrong Yang1 Shujun Cheng1 Wen Zhang2 Lin Feng1 and Kaitai Zhang1 Abstract Activated Cdc42-associated kinase 1 ACK1 a kind of tyrosine kinase is considered to be an oncogene in many can- cers and it is likely to become a potential target for cancer treatment. We found that the expression of the ACK1 gene in colon cancer was higher than that in normal tissues adjacent to cancer and high expression of the ACK1 gene was associated with poor prognosis of patients. We assessed the prognosis of colon cancer based on ACK1-related genes and constructed a model that can predict the prognosis of colon cancer patients in colon cancer data from The Can- cer Genome Atlas TCGA database. We then explored the relationship between ACK1 and the immune microenviron- ment of colon cancer. The overexpression of ACK1 might hinder the function of antigen-presenting cells. The colon cancer prognosis prediction model we constructed has certain significance for clinicians to judge the prognosis of patients with colon cancer. The expression of the ACK1 gene might affect the infiltration level of a variety of immune cells and immunomodulators in the immune microenvironment. Keywords ACK1 Colon cancer Prognosis Immune infiltration Background Until recently the gene targets of precision therapy Colon cancer is a major health burden worldwide and drugs mainly included MSI 30 BRAF 1 KRAS 7 the incidence of colon cancer is on the rise 5 . At pre- NRAS 21 HER2 10 NTRK 23 etc. However these sent the treatment of colon cancer is mainly based on findings still cannot meet the needs of the many colon traditional treatments such as surgery radiotherapy and cancer patients with different molecular types. There- chemotherapy. With in-depth research on the mecha-
