According to existing literature, the western segment of the Manisa Fault Zone is well known characterized; however, the eastern segment of it has rarely been addressed. To decipher the Holocene seismotectonic behavior of the eastern segment of Manisa Fault Zone, trench-based paleoseismological analyses for the first time were performed along with it. To constrain the timing and frequency of past earthquakes, and elapse time from the last activation using the optically stimulated luminescence (OSL) and radiocarbon (14C) dating, we collected twenty-six colluvial and paleosol samples from the trenches. | Turkish Journal of Earth Sciences Turkish J Earth Sci 2021 30 806-832 http earth TÜBİTAK Research Article doi yer-2109-3 Paleoseismic history of the Manisa fault zone Western Anatolia 1 2 3 1 2 2 İsmail DURAN Hasan SÖZBİLİR Semih ESKİ Mustafa SOFTA 4 5 5 Hüseyin UYTUN Mehmet YÜKSEL Mustafa TOPAKSU 1 The Graduate of Natural and Applied Sciences Applied Geology Dokuz Eylül University İzmir Turkey 2 Department of Geological Engineering Faculty of Engineering Dokuz Eylül University İzmir Turkey 3 Earthquake Research and Implementation Center of Dokuz Eylül University İzmir Turkey 4 Investment Monitoring and Coordination Directorate İzmir Governorship Manisa Turkey 5 Department of Physics Faculty of Arts-Sciences Çukurova University Adana Turkey Received Accepted Published Online Final Version Abstract The 45-km-long E-W to NW-SE-striking Manisa Fault Zone which constitutes the western section of the Gediz Graben is characterized by a pure normal sense of motion with a minor strike-slip component. Even though there are numerous historical earthquakes have been listed in Western Anatolia Graben System a few studies have been addressed on seismic sources of the earthquakes so far. According to existing literature the western segment of the Manisa Fault Zone is well known characterized however the eastern segment of it has rarely been addressed. To decipher the Holocene seismotectonic behavior of the eastern segment of Manisa Fault Zone trench-based paleoseismological analyses for the first time were performed along with it. To constrain the timing and frequency of past earthquakes and elapse time from the last activation using the optically stimulated luminescence OSL and radiocarbon 14C dating we collected twenty-six colluvial and paleosol samples from the trenches. The obtained paleoseismic data show that i Manisa Fault Zone is responsible for six surface rupturing earthquakes since late .