To establish and validate the methods to assay verapamil hydrochloride (VH) in gastric floating tablets by high performance liquid chromatography (HPLC). Materials and methods: The method was developed according to the monograph of VH extended-release tablets in the USP 43; the method was validated based on the ICH guidelines, including System suitability, selectivity, linear range, repeatability, accuracy, the limit of detection (LOD), the limit of quantification (LOQ). |
