The results revealed that ME treatment decreased body weight and fat mass including visceral adipose tissue, epididymal white adipose tissue, subcutaneous adipose tissue. The results suggest that ME is effective in reducing weight and adipose tissue mass in HFD-fed mice. | BÁO CÁO KHOA HỌC VỀ NGHIÊN CỨU VÀ GIẢNG DẠY SINH HỌC Ở VIỆT NAM - HỘI NGHỊ KHOA HỌC QUỐC GIA LẦN THỨ 5 DOI EFFECT OF MANGOSTEEN Garcinia mangostana L. PEEL EXTRACT ON WEIGHT LOSS AND ADIPOSE TISSUE MASS IN MICE Nguyen Duong Anh Hong1 Dam Hoang Linh1 Le Thi Tuoi1 Do Thi Nhu Trang1 Duong Thi Anh Dao1 Nguyen Thi Trung Thu1 Le Thi Tuyet1 Abstract. Mangosteen Garcinia mangostana L. peel contains some secondary metabolites such as xanthones. The present study aimed to investigate the effect of extract from mangosteen peel on the potential weight loss and reducing adipose tissue mass in mice. Male mice fed an high-fat diet HFD for 8 weeks were supplemented with mangosteen peel extract ME 200 mg kg day for an additional 6 weeks while mice fed a standard diet SD were used as normal controls. The results revealed that ME treatment decreased body weight and fat mass including visceral adipose tissue epididymal white adipose tissue subcutaneous adipose tissue. The results suggest that ME is effective in reducing weight and adipose tissue mass in HFD-fed mice. Keywords Mangosteen peel extract weight loss adipose tissue mice. 1. INTRODUCTION In the past obesity was considered a problem only in high-income countries but in the past few decades it has emerged in both low- and middle-income countries with a high prevalence of obesity and rates are increasing especially in urban areas. High body fat mass in obese people leads to serious medical complications including hypertension type 2 diabetes steatosis and some other types of cancer reducing the quality of life and life expectancy of people. Current obesity treatment involves many aspects such as lifestyle changes bariatric surgery or pharmaceutical therapy Alamuddin et al. 2016 . Among them measures related to lifestyle changes such as dietary management by reducing total energy intake Shinde et al. 2021 and exercise are considered fundamental for the prevention and treatment of obesity. However this .
