Nghiên cứu tần số kiểu gen, tần số alen đa hình CYP2E1*5B và CYP2E1*7B ở nhóm người Việt Nam sinh sống tại một số tỉnh phía Bắc

Nghiên cứu tần số kiểu gen, tần số alen đa hình CYP2E1*5B và CYP2E1*7B ở nhóm người Việt Nam sinh sống tại một số tỉnh phía Bắc trình bày việc xác định khả năng ảnh hưởng của các đa hình này đến quá trình biểu hiện gen CYP2E1 làm cơ sở để nghiên cứu mối liên quan đến các bệnh được chẩn đoán do rượu. | TNU Journal of Science and Technology 228 01 211 - 218 STUYDING ON GENOTYPE AND ALLELE FREQUENCY OF CYP2E1 5B AND CYP2E1 7B POLYMORPHISM AT A VIETNAMESE GROUP LIVING IN THE NOTHERN PROVINCES Bui Thi Thu Huong1 Nguyen Phuong Thao2 Nguyen Thi Yen2 Hoang Thi Thu Yen2 1TNU - University of Medicine and Pharmacy 2TNU - University of Sciences ARTICLE INFO ABSTRACT Received 21 7 2022 Cytochrome P450 family 2 subfamily E member 1 CYP2E1 converts ethanol to acetaldehyde and reactive oxygen species that can cause liver damage and develope Revised 04 11 2022 liver cancer in alcoholics. CYP2E1 5B T CYP2E1 7B T of CYP2E1 5B C-1053T Published 23 11 2022 rs2031920 rs3813867 and CYP2E1 7B polymorphisms G-71T rs6413420 belong to the regulation region 5 -flanking region is thought to enhance in CYP2E1 gene transcription. In this study we determined allele and genotype frequency of KEYWORDS CYP2E1 5B and CYP2E1 7B in 96 Vietnamese individuals for health checking and Alcohol abuse treatment at Thai Nguyen national hospital by identifying and nucleotide sequence analyzing. In 96 research individuals 65 individuals were for the wild homozygous Cytochrome P450 family 2 genotype CYP2E1 5B CC with the highest rate of 29 individuals with subfamily E member 1 CYP2E1 heterozygous genotype CYP2E1 5B CT ranked second accounting for mutant CYP2E1 5B homozygous genotype CYP2E1 5B TT has the lowest rate of with 2 cases. The CYP2E1 7B allele frequency of the mutant variant CYP2E1 5B T in the study population isn t small . While CYP2E1 7B is not polymorphic 100 of individuals have wild rs6413420 homozygous genotype CYP2E1 7B GG. Thus ethanol metabolism in this study rs2031920 population was not affected by the CYP2E1 7B polymorphism while CYP2E1 5B could have differences in the expression of the CYP2E1 gene. This study highlights the need to study the relationship of CYP2E1 5B polymorphisms in alcholism Vietnamese living in the northern provinces and suffer from related .