Bài viết trình bày so sánh kết quả điều trị viêm nang lông vảy phấn bằng uống ivermectin kết hợp bôi metronidazol 1% với liệu pháp uống và bôi metronidazol kết hợp. Ivermectin uống kết hợp metronidazol bôi cho kết quả tương đương, ít tác dụng phụ hơn so với metronidazol uống và bôi kết hợp trong điều trị viêm nang lông vảy phấn. | Vietnam Journal of Community Medicine Vol. 64 Special Issue 2023 198-203 INSTITUTE OF COMMUNITY HEALTH COMPARE THE OUTCOMES OF THE TREATMENT OF DEMODICOSIS BY COMBINING ORAL IVERMECTIN WITH TOPICAL METRONIDAZOL 1 AND COMBINING ORAL WITH TOPICAL METRONIDAZOL THERAPY Trần Cẩm Vân National Hospital of Dermatology and Venereology - 15A Phuong Mai Hanoi Vietnam Received 15 12 2022 Revised 26 01 2023 Accepted 28 02 2023 ABSTRACT Objectives To compare the outcomes of the treatment of pityriasis folliculitis by combining oral ivermectin with topical metronidazol 1 and combining oral with topical metronidazol therapy. Method Controlled comparative clinical trial. 70 patients with pityriasis folliculitis were randomly divided into 2 groups 35 patients in group one were managed with oral ivermectin one dose of 200 µg kg and topical metronidazol 1 . 35 patients in group two were managed with oral metronidazol doses 500 mg per day for 2 weeks and topical metronidazol 1 . Demodex was detected by standardized skin surface biopsy. The study subjects were followed-up after 2 and 4 weeks. Result After 2 and 4 weeks pruritus red papules red patchs skin scabs in both groups reduced differences between the two groups had no significance p gt 0 05 . Group one had greater reduction in Demodex density than group two p lt 0 05 . At week 4 in the group which treated by oral ivermectin and topical metronidazol 80 had good improvement 14 3 had moderate improvement and 5 7 had little improvement. Meanwhile in the group which treated by combining oral and topical metronidazol therapy the rates were 71 4 22 9 and 5 7 respectively. The outcomes of the treatment in both groups had no significant difference p gt 0 05 . Side effects including pruritus burning in group one were lower than group two p lt 0 05 . Conclusion Oral ivermectin combined with topical metronidazol showed similar outcomes less side effects than oral combined topical metronidazol in management of pityriasis folliculitis. .
