Mesoporous silica nanoparticles (MSNs) have been used as an anticancer drug delivery system with high safety and entrapment capacity thanks to their large internal space for drug accommodation, durable structure, and good biocompatibility. However, the treatment efficiency of the bare MSNs is limited due to its drug leakage and burst release. In this study, a phospholipid bilayer was covered on the MSNs surface (MSN@Lip) as a liposomal cap that not only reduced drug leakage but also improved the stability of the colloidal system. | Cite this paper Vietnam J. Chem. 2023 61 S3 51-58 Research Article DOI Development of liposome capped mesoporous silica nanoparticle for anticancer drug delivery Dinh Tien Dung Nguyen1 2 Ngoc Hoi Nguyen1 3 Ngoc-Hang Truong-Thi2 Yern Chee Ching4 Tan Phu Nguyen2 Dai Hai Nguyen3 1 Graduate University of Science and Technology Vietnam Academy of Science and Technology Hanoi 10000 Viet Nam 2 Institute of Applied Materials Science Vietnam Academy of Science and Technology 01B TL29 District 12 Ho Chi Minh City 70000 Viet Nam 3 Institute of Chemical Technology Vietnam Academy of Science and Technology 01A TL29 District 12 Ho Chi Minh City 70000 Viet Nam 4 Department of Chemical Engineering Faculty of Engineering University of Malaya Kuala Lumpur 50603 Malaysia Submitted February 18 2023 Revised June 7 2023 Accepted June 23 2023 Abstract Mesoporous silica nanoparticles MSNs have been used as an anticancer drug delivery system with high safety and entrapment capacity thanks to their large internal space for drug accommodation durable structure and good biocompatibility. However the treatment efficiency of the bare MSNs is limited due to its drug leakage and burst release. In this study a phospholipid bilayer was covered on the MSNs surface MSN@Lip as a liposomal cap that not only reduced drug leakage but also improved the stability of the colloidal system. The chemical structure of MSNs and MSN@Lip was characterized by Fourier transform infrared spectroscopy FT-IR and energy-dispersive X-ray spectroscopy EDX . The particle size and morphology were determined by dynamic light scattering DLS . The results demonstrated that the MSN@Lip was successfully synthesized with the hydrodynamic diameter and zeta potential of nm and mV respectively. The optimal condition was sonication for 30 minutes at 60 C with the Lip-MSNs ratio as 3 1 w w . The SEM images showed that MSN@Lip has a spherical shape with high monodispersity. Releasing .
