Pharmaceutical Substances Syntheses, Patents, Applications - Part 28

Pharmaceutical Substances Syntheses, Patents, Applications - Part 28. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Bromocriptine B 271 Bromocriptine ATC G02CB01 N04BC0i 2-Bromoergocryptine Use Pr actin inhibitor RN 25614-03-3 MF C32H40BrN5O5 MW EINECS 247-128-5 LDW 800 mg kg M . 72 mg kg R . CN 5la -2-bromo-12 -hydroxy-2 - l-methylethyl -5 - 2-methylpropyl ergotaman-3 6 18-trione monomesylate RN 22260-51-1 MF C32H40BrN5O5 CH4O3S MW EINECS 244-881-1 LDJ0 189 mg kg M . 2502 mg kg M . mg kg R . 2 g kg R . ergocryptîne N-bromo- succinimide Reference s US 3 752 814 Sandoz CH-prior. . DAS 1 926 045 Sandoz appl. CH-prior. . medical use US 3 752 888 Sandoz CH-prior. . nasal formulation DOS 2 802 113 Sandoz appl. . Formulation s cps. 5 mg 10 mg tabl. mg as mesylate Trade Name s D Kirim Hormosan Pravidel Novartis Pharma GB Parlodel Novartis 1978 J Parlodel Novartis 1979 Parlodel Novartis 1976 USA Parlodel Novartis 1976 1977 I F Bromo-Kin Irex Parlodel Sandoz 1979 Serocryptin Serono Bromopride ATC A03FA04 Use anti-emetic gastric therapeutic RN 4093-35-0 MF Cl4H22BrN3O2 MW EINECS 223-842-2 LDSO 310 mg kg M . 545 mg kg R . CN 4-amino-5-bromo-7V- 2- diethylamino ethyl -2-methoxybenzamide 272 B Bromopride h2n -xxn CH k CH3 AI OCH CH3 2 3 -------------- 4-acetamido-N- 2-diethyl- aminoethyl -2-methoxy- benzamide III methyl 4-acetomido- N N-dîethyl- 2-methoxybenzoote I ethylenediamine II 1. Br CH COOH 2. HCl III ------------------ COOH nh2 JL JL H3C O CH3 acetic anhydride 4-amino- methanol methyl 4-amîna- salicylic acid salicylate ch3 . y- HN CH. n 0 O methyl 4-acetamido- salicylate IV IV s 0-ch3 H3C OZ 0 dimethyl sulfate Br2 CH3COQH methyl 4-acetamido-5-broma-2-methaxybenzaate 1. n ai och ch3 2 3 2. HCl . Bromapride Reference s US 3 177 252 Soc. d Etudes Scientifiques et Industrielles de l Ile-de-France . 1965 F-prior. . US 3 219 528 Soc. d Etudes Scientifiques et Industrielles de l Ile-de-France F-prior. . US 3 357

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