Pharmaceutical Substances Syntheses, Patents, Applications - Part 33. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Calcium dobesilate c 321 II 0 Br NaHCO3 hexane 1 3-dibromo-5 5-di-methylhydantain Reference s US 3 993 675 Hoffmann-La Roche Inc. prior. . alternative synthesis - DOS 2 754 759 Chugai Seiyaku appl. J-prior. . Semmler . et al. Tetrahedron Lett. TELEAY 1972 4147. Barton . et al. J. Chem. Soc. Chem. Commun. JCCCAT 1974 203. synthesis of la 25-dihydroxycholesterol DOS 2 453 648 Hoffmann-La Roche appl. USA-prior. . Formulation s amp. 1 pg ml 2 Jlg ml cps. Trade Name s D Rocaltrol Roche I Calcijex Abbott USA Calcijex Abbott F Rocaltrol Roche Rocaltrol Roche Rocaltrol Roche Labs. GB Rocaltrol Roche J Rocaltrol Roche-Kyorin Calcium dobesilate Dobesilate de calcium ATC C05BX01 Use hemostatic capillary protective RN 20123-80-2 MF C12H10CaO10S2 MW EINECS 243-531-5 LD50 775 mg kg M . 7549 mg kg M . 7061 mg kg R . CN 2 5-dihydroxybenzenesulfonic acid calcium sait 2 1 322 C Calcium hopantenate 1 4-benzo-quinone Ca HSO3 2 calcium hydragen sulfite Reference s US 3 509 207 Lab. Om CH-prior. . Formulation s cps. 250 mg tabl. 250 mg Trade Name s D Dexium Synthelabo Dobica OPW F Doxium Synthelabo I Dobesifar Farmila Doxiproct-Plus Delalande Isnardi -comb. Doxium Delalande Isnardi Calcium hopantenate ATC N06B Use cerebral activator RN 17097-76-6 MF C20H36CaN2O10 MW CN Æ -4- 2 4-dihydroxy-3 3-dimethyl-l-oxobutyl amino butanoic acid calcium salt 2 1 hopantenic acid RN 18679-90-8 MF C1 IH19NO5 MW LD50 2250 mg kg M . 5720 mg kg M route unreported hn c2h5 2 ch3oh diethylamine H3c 0 HO T A COOH H2N x COOH h3c oh h pantothenic acid cf. calcium pontathenate J-LC 0 H0 r N x C00H H-jC OH H Reference s Kopelevich . et al. Khim. Farm. Zh. KHFZAN 5 21 1971 . JP 26 189 64 Takeda appl. . alternative syntheses McFall Desha C. Fuerst R. Biochim. Biophys. Acta BBACAQ 86 33 1964 . JP 732 66 Tanabe appl. . review Nishizawa Y Kodama T
