Pharmaceutical Substances Syntheses, Patents, Applications - Part 39. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Cefditoren pivoxil C 381 Formulations vial 500 mg 1 g Trade Name s J Keiperazon Kaken 1985 Tomiporan Toyama 1985 Cefditoren pivoxil ATC soiaa ME-1207 se cephalosporin RN 117467-28-4 MF C25H28N6O7S MW CN 6Ä- 3 Z 6a 7ß Z -7- 2-amino-4-thiazolyl methoxyirmno acetyl amino -3- 2- 4-methyl-5-thiazolyl ethenyl -8-oxo-5-thia-1 -azabicyclo oct-2-ene-2-carboxylic acid 2 2-dimethyl-1-oxopropoxy methyl ester 6R- 3 Z 6a 7ß E -form RN 104145-87-1 MF C25H28N6O7S3 MW 4-methoxybenzyl 3- chloro-methyl -7 R - pheny acetamido -3-cephem-4-carboxylate 1. P C6H5 3 Nol ocetone CHO 2. Sx CH3 1 2 NaHCOj- CH2CI2 V N 1. triphenylphosphine sodium iodide 2. 4-methylthiazole-5-carboxoldehyde 0 PC s. -30 C ------------- phosphorus pentachloride in pyridine D 4- 1. PQChj 2. r3c COOH l jT CH --------------------------m 2. trifluoroacetic 2 methoxyimino -2- 2-tritylamina-thiazol-4-yl acetic acid acid in anisole COOH F3C-COOH ni 1. NaHCOj H2O 2. Dioion HP2O chromatography 382 C Cefixime iodomethyl pivalate Cefditoren pivoxil Reference s synthesis EP 175 610 Meiji Seika Kaisha appl. J-prior. . Sakagami K. et al. J. Antibiot. JANTAJ 43 8 1047 1990 . Sakagami K. et al. Chem. Pharm. Bull. CPBTAL 39 9 2433 1992 . pharmaceutical compositions EP 339 465 Meiji Seika Kaisha appl. J-prior. . EP 629 404 Meiji Seika Kaisha appl. J-prior. . Formulation s gran. 100 mg tabl. 100 mg Trade Name s J Meiact Meiji Seika Cefixime CL-284635 FK-027 FR-17027 ATC J01DA23 Use semisynthetic third generation cephem antibiotic for oral administration high P-lactamase stability RN 79350-37-1 MF C16H15N5O7S2 MW LD50 4420 mg kg M . 10 g kg M . 6990 mg kg R . 10 g kg R . 3200 mg kg dog . 600 mg kg dog . CN 67 - 6a 7p Z -7- 2-amino-4-thiazolyl carboxymethoxy imino acetyl amino -3-ethenyl-8-oxo-5-thia-1 -azabicyclo oct-2-ene-2-carboxylic acid trihydrate RN 125110-14-7 MF C16H15N5O7S2 3H O MW Cefixime 383 .
