Pharmaceutical Substances Syntheses, Patents, Applications - Part 75. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Enalaprilat E 741 ethyl 2-oxo-4-phenylbutyrate Weinstock . et al. Synth. Commun. SYNCAV 11 943 1981 . a Wyvratt . et al. J. Org. Chem JOCEAH 49 2816 1984 . US 4 374 829 Merck Co. prior. . EP 12401 Merck Co. appl. USA-prior. . US 4472 380 Merck Co. . 1984 prior. . Huffmann . et al. Tetrahedron Lett. TELEAY 40 331 1999 . b US 4 442 030 Merck Co. prior. . c Blacklock . et al. J. Org. Chem. JOCEAH 53 836 1988 . processes which employ reaction of activated derivatives ofN- ỉ S -ethoxycarbonyl-3-phenylpropyl -L-alanine with L-proline US4716 235 Kanegafuchi J-prior. . DOS 3 542 735 Uriach appl. E-prior. . US4652 668 Biomeasure appl. . condensation o L-alanyl-L-proline with 3-phenylpropionaldehyde and cyanides via the corresponding aminonitrile EP79 521 Merck Co. appl. USA-prior. . Formulation s tabl. mg 5 mg 10 mg 20 mg as hydrogen maleate Trade Name s D Pres Boehringer Ing. GB Innovace Merck Sharp Naprilene Sigma-Tau F 1984 Xanef Merck Sharp Dohme 1984 Co-Renitec Merck Sharp I Dohme 1986 Innozide Merck Sharp Dohme -comb. Converten Neopharmed 1985 J Renivace Banyu 1986 USA Lexxel Astra Merck Vaseretic Merck 1987 - Dohme-Chibret -comb. Renitec Merck Sharp Dohme-Chibret 1985 1985 Enapren Merck Sharp Dohme 1985 comb. with hydrochlorothiazide Vasotec Merck 1986 Enalaprilat C09AA02 C09BA02 Enalaprilic acid Use angiotensin-converting enzyme inhibitor for . application as antihypertensive and in congestive heart failure active metabolite of enalapril q. v. RN 76420-72-9 MF C18H24N2O5 MW EINECS 278-459-3 CN S -l- A- l-carboxy-3-phenylpropyl -L-alanyl -L-proline dihydrate RN 84680-54-6 MF C18H24N2O5 2H2O MW enolop ril q-u aq. NaOH ----- Enalaprilat E 742 Endralazine Reference s Palchett A. A. et al. Nature London NATUAS 288 280 1980 . Wyoratt . et al. J. Org. Chem. JOCEAH 49 .
