Pharmaceutical Substances Syntheses, Patents, Applications - Part 87. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Flecainide F 861 hydrochloride RN 3717-88-2 MF C24H25NO4 HCl MW EINECS 223-066-4 LD5o 28 mg kg M . 740 mg kg M . 25 mg kg R . 1040 mg kg R . COOH 0 V 1 soltcylic propionyl COOH aûrcHj 2-propionyloxy-benzoic acid aici3 3-propionyl- acid chloride 0 0 benzoic anhydride sodium benzoote solicylic acid 1 8-chloroformyl- 1- 2-hydraxy- 3-methylflavone II ethyl piperîdine 8-carboxy-3-methylflavone Reference s US2 921 070 Recordati CH-prior. . alternative synthesis US3 350411 Seceph I-prior. . Formulation s f. c. tabl. 200 mg tabl. 100 mg as hydrochloride Trade Name s . D Spasuret Sanofi Winthrop F Urispas Negma GB Urispas Shire 1 Cistalgan Recordati - comb. Genurin Recordati J Bladderon Nippon Shinyaku USA Urispas SmithKline Beecham Flecainide ATC C01BC04 Use antiarrhythmic RN 54143-55-4 MF C17H20F6N2O3 MW CN A- 2-piperidinylmethyl -2 5-bis 2 2 2-trifluoroethoxy benzamide acetate RN 54143-56-5 MF C17H20F6N2O3 C2H4O2 MW 862 F Fleroxacin COOH Ax h 2 5-dihydroxy-benzoic acid W O CF 4- 0 F C X xX 0 2 2 2-trifluoro-ethyl trifluoromethonesulfonote O O CFj p NoHCOj LxO. Ci 3 H2N 2-aminomethyl- pyridine 2 2 2-trifluoroethyl 2 5-bis 2 2 2-trifluoro- ethoxy benzoote Reference DE 2 513 916 Riker prior. . . US 3 900 481 Riker prior. . US 3 655 728 Riker prior. . US 4 005 209 Riker prior. . Bannit . et al. J. Med. Chem. JMCMAR 18 1130 1975 20 821 1977 . Formulation s amp. 50 mg tabl. 50 mg 100 mg as acetate Trade Name s D Tambocor 3M Medica GB Tambocor 3M Health J Tambocor Eisai 1982 Care 1983 USA Tambocor 3M 1985 F Flécame 3M Santé 1984 I Almarytm Synthelabo 1986 Fleroxacin ATC J01MA08 AM 833 Ro 23-6240 Megalocin Use antibacterial RN 79660-72-3 MF C 7HI8F3N3O3 MW LD5 1 mg kg R i. v. 4 g kg R p. o. mg kg M i. v. 4 g kg M p. o. 1 g kg dog p. o. CN 6 8-Difluoro-l- 2-fluoroethyl -l 4-dihydro-7- 4-methyl-l-piperazinyl .