Pharmaceutical Substances Syntheses, Patents, Applications - Part 93. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Fluvastatin sodium F 921 nortropîne N- 0-fluoroethyl - nortropine H N- 0-fluoroethyl nor- tropine benzilate V V ÎV Flutropium bromide Reference s DE2 540 633 Boehringer Ing. appl. . Banholzer R. etal. . ARZNAD 36 1161 1986 . synthesis of nortropine benzilate Bertholdt H. et al. . ARZNAD 17 719 1967 Trade Name s J Flubron S. S. Pharm. Fluvastatin sodium SRI-62320 XU-62-320 XU-620 ATC B04AB04 Use hyperlipidemic HMG-CoA-reductase inhibitor RN 93957-55-2 MF C24H25FNNaO4 MW CN 7 5 - - -7- 3- 4-fluorophenyl -l- l-methylethyl -lI7-indol-2-yl -3 5-dihydroxy-6-heptenoic acid monosodium salt free acid RN 93957-54-1 MF C24H26FNO4 MW h3c -ch3 F ethyl 3- 4-fluoro-phenyl -1 -isopropyl -indole-2-corboxylate 1. hai ch2ch ch3 2 2 toluene. THF -78 C 2 MnX 2 Et2O 1. diisobutylaluminum hydride 3- 4-fluorophenyl - 1 -isopropylindole-2-carboxoldehyde I 922 F Fluvastatin sodium F E -3- 3- 4 fluoro-phenyl -1 -îsopropyl-indol-2-yl -propenal 2- tributylstonnyl vinyl ethyl ether II Q O NoH THF -15 C h3c -ch3 methyl ocetoocetote methyl - E -7- 3- 4-fluoro-phenyl -1 -isopropylindol-2-yl -5-hydroxy-3-oxohept-6-enoate III 1. h3c 3c-nh2 bh3 c2h5oh 2. separation of the diastereomers in ----------------------------------- methyl -erythro- E -3 5-dihydraxy- 7- 3- 4-fluorophenyl -1 -isopropyl- indol-2-yl hept-6-enoate IV NaOH C2H5OH IV ---------------- 1. POCI3 ch3-cn 2. H20 n 3- methylphenyl-omino acrolein Fluvastatin sodium F 92 u H3C CH-j NaH. BuU THF ----------------- H3VCH3 tert-butyl - E -7- 3- 4-fluoro-phenyl -1 -isopropylindol-2-yl -5-hydroxy-3-oxohept-6-enoöte VI tert-buty acetoacetate 1. ch3ob c2h5 2 NaBH4 THF CH30H stereoselective reduction 2. H202. ethyl acetate hydrolysis of the cyclic boronate ------------------------------------- 1. diethylmethoxybarane tert-butyl i -erythro- E - 7- 3- 4-fluorophenyl -1 -isopropyl- indol-2-yl -3 5-dihydroxy- hept-6-enaote VII NoOH THF 10 C ----------------- Fluvastatin sodium aoj synthesis of 3- .
