Pharmaceutical Substances Syntheses, Patents, Applications - Part 98. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Glipizide G 971 Glipizide ATC A10BB07 Use antidiabetic RN 29094-61-9 MF C2JH27N5O4S MW EINECS 249-427-6 LD5l 3 g kg M i P- 1200 mg kg R . CN V- 2- 4- cyclohexylamino carbonyl amino sulfonyl phenyl ethylJ-5-methylpyrazinecarboxamide .cV 5-methylpyrazine- 2-corboxylic acid 1. SOCI2 1. thionyl chloride 2. 4- 2-aminoethyl -benzenesulfonamide I cyclohexyl isocyanate NoOH Reference s DAS 2012 138 Carlo Erba appl. Eprior. . ƯS 3 669 966 Carlo Erba Eprior. . Ambrogli V. et al . ARZNAD 21 200 1971 . preparation ớ 5-methylpyrazinc-2-carboxylic acidfrom 2 5-dimethylpyrazine via oxidation Stoehr J. Prakt. Chem. JPCEAO 2 51 464 1895 Stoehr J. Prakt. Chem. JPCEAO 2 47 480 1893 . Kiener A. Angew. Chem. ANCEAD 104 6 748 1992 . Goldberg Yu. Shymanska M. Org. Prep. Proced. Int. OPPIAK 23 2 188 1991 . electrochemical preparation ớ 5-methylpyrazine-2-carboxylic acid Borsotti . Foh M. Gatti N. Synthesis SYNTBF 1990 3 207. Feldman D. et al. Chem. Heterocycl. Compd. N. Y. CHCCAL 31 1 80 1995 . Formulation s tabl. mg 5 mg 10 mg Trade Name s D Glibenese Pfizer 1977 F Glibénèse Pfizer 1974 Minidiab Pharmacia Upjohn 1974 Ozidia cp à lib modifiée CC Pfizer GB Glibenese Pfizer 1975 Minodiab Pharmacia Upjohn 1975 I Minidiab Carlo Erba 1972 USA Glucotrol Pfizer 1984 Gliquidone ATC A10BB08 Use antidiabetic RN 33342-05-1 MF C27H33N3O6S MW EINECS 251-463-2 LD50 234 mg kg M . 2g kg M . CN A4 cyclohexylamino carbonyl -4- 2- 3 4-dihydro-7-methoxy-4 4-dimethyEl 3-dioxo-2 lH - isoquinolinyl ethyllbenzenesulfonamide 972 G Glisoxepide trimethyl- tetrahydro-isoquinoline-1 3-diane 1. hno3 2. H2 Roney Ni 3. NoNO2 4. oq. H2SO 11 -O . 0 5- 3 X OZ r CH3 7-methoxy-2 4 4-trimethyl-1 2 3 4-tetrahydroiso-quinoline-1 3-dione 1. NoOH 2. H2SO4 _ i- i 4 4-dimethyl-7- 4- 2-ominoethyl - methoxyisochroman- benzenesulfonamide cyclahexyi- potassium isocyanate tert-butylate Reference s DAS 2 000 339
