Pharmaceutical Substances Syntheses, Patents, Applications - Part 133. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Mezlocillin M 1321 Reference s US 3 954 872 Boehringer Ing. D-prior. . DE 1 543 369 Boehringer Ing. prior. . composition and use US 4 031 244 Boehringer Ing. D-prior. . Formulation s amp. 25 mg ml 250 mg 10 ml cps. 100 mg 150 mg 200 mg s. r. cps. 360 mg as hydrochloride Trade Name s D Mexitil Boehringer Ing. 1979 GB Mexitil Boehringer Ing. 1976 J Mexitil Boehringer Ing. 1985 F Mexitil Boehringer Ing. 1980 I Mexitil Boehringer Ing. 1982 USA Mexitil Boehringer Ing. 1986 generics Mezlocillin ATC J01CA10 Use antibiotic RN 51481-65-3 MF C2lH25N5O8S2 MW EINECS 257-233-8 CN 25- 2a 5a 6ß S -3 3-dimethyI-6- 3- methylsulfonyl -2-oxo-l- imidazolidinyl carbonyl amino phenylacetyl amino -7-oxo-4-thia-l-azabicyclo heptane-2-carboxylic acid monosodium salt RN 42057-22-7 MF C2 H24N5NaO8S2 MW EINECS 255-640-5 LD50 6329 mg kg M . 16 g kg M . 2636 mg kg R . 20 g kg R . 0 II H C S CI 3 II 0 methanesulfonyl chloride n o 2-imida-zolidinöne 1 -methanesulfonyl- 2-imidazalidinone 1. CH3 3sra n c2h5 3 2. COCI2 k 1. trimethylchlorosilane tnethylomine 2. phosgene COOH 0 0 Vnvn H3C 0 0 N C2H5 3 pH 7-8 --------- Mezlocillin COOH sXch3 3-chloroformyl- 1 -methanesulfonyl- 2-imidozolidinane I ampicillin q. V. Reference s DOS 2 152 967 Bayer appl. . DOS 2 152 968 Bayer appl. . DOS 2 318 955 Bayer appl. . US 3 974 142 Bayer appl. D-prior. . combination with e. g. oxacillin DOS 2 737 673 Bayer appl. . 1322 M Mianserin Formulation s vial 5 ml 1 g 10 ml 2 g 20 ml 5 g 50 ml Trade Name s D Baypen Bayer Vital 1977 Melocin curasan Optocillin Bayer Vital 1979 -comb. with oxacillin F Baypen Bayer-Pharma GB Baypen Bayer 1980 wfm I Baypen Bayer 1983 J Baypen Yoshitomi 1982 USA Mezlin Bayer 1981 Mianserin ATC N06AX03 Use antidepressant RN 24219-97-4 MF C18H20N2 MW EINECS 246-088-6 LD 0 365 mg kg M . CN l 2 3 4 10 .
