Pharmaceutical Substances Syntheses, Patents, Applications - Part 198. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Tandospirone T 1971 I Omnic Yamanouchi USA Flomax Boehringer J Harnal Yamanouchi Ingelheim 1997 Tandospirone ATC N05BX SM-3997 as citrate Use anx olytic antidepressant RN 87760-53-0 MF C21H2S N5O2 MW CN 3aa 4ß 7ß 7aa -hexahydro-2- 4- 4- 2-pyrimidinyl -l-piperazinyl butyl -4 7-methano lH-isoindole- 1 3 2Z7 -dione citrate RN 112457-95-1 MF C2IH29N5O2 . C6H8O7 MW 1- pyrimidin-2-yl -piperazine 1. NaOH H2O hAu 2. LiAIH4 -------2-------------------Ï 4- 4- pyrímidỉn-2-yl -piperazin-1 -yljbutylamine I C 2. Hj cat. ---L----- nortorn-5-ene- ocid anhydride norbarnane-2exo 3exo-dicarboxylic acid anhydride n pyridine A II -------------- I Reference s EP 82 402 Sumitomo Chem. appl. J-prior. . IP60 087 262 Sumitomo Chem. appl. USA-prior. . JP 63 010 760 Sumitomo Chem. appl. J-prior. . use ớ tandospirone a treating depression US 5 011 841 Pfizer appl. USA-prior. . b as psychotropic agents US 5 521 313 Bristol-Myers Squibb appl. USA-prior. . c as 5-HTịA-receptor agonist WO 9 605 817 Medinova SF appl. GB-prior. . 1972 T Tazanolast dosage forms US 5 330 762 Alza Corp. appl. USA-prior. . US 5 246 711 Alza Corp. appl. USA-prior. . US 5 246 710 Alza Corp. appl. USA-prior. . US 5 185 158 Alza Corp. appl. USA-prior. . synergistic compositions with 8-hydroxy-2- dipropylamino tetraline and idazoxan US 5 124 346 Pfizer appl. USA-prior. . synthesis ofl Kikuo I. et al. Chem. Pharm. Bull. CPBTAL 39 2288 1991 . Wu et al. J. Med. Chem. JMCMAR 15 477 1972 . Formulation s tabl. 5 mg 10 mg Trade Name s J Sediel Sumitomo Tazanolast ATC R03DX Use antiallergic antiasthmatic RN 82989-25-1 MF C13H15N5O3 MW LD50 1121 mg kg M . 4 g kg M . 1119 mg kg R . 4 g kg R . 4 g kg dog . CN oxo 3- .
