Pharmaceutical Substances Syntheses, Patents, Applications - Part 216. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Urokinase U 2151 1 3-dimethyl-6- 3-chloropropylamino -uracil 1 - 2-methoxypheny -piperazine carbonate Reference s DE 1 942 405 Byk Gulden appl. . US 3 957 786 Byk Gulden D-prior. . US 4 067 982 Byk Gulden prior. . addition compound with furosemide GB 1 512 771 Byk Gulden appl. L-prior. . Formulation s amp. mg mg as hydrochloride amp. 25 mg 50 mg cps. 30 mg 60 mg as fumarate s. r. cps. 30 mg 60 mg 90 mg Trade Name s D Alpha-Depressan OPW Eupressyl gél Byk I Ebrantil-30 -60 Byk Ebrantil Byk Gulden Mediatensyl gél Débat Gulden as fumarate F Eupressyl Byk as cardio Ebrantil-50 Byk Gulden hydrochloride J Ebrantil Kaken Urokinase ATC B01AD04 Use plasminogen activator fibrinolytic RN 9039-53-6 MF unspecified MW unspecified EINECS 232-917-9 LD50 3000000 iu kg M . mg kg M . 3000000 iu kg R . mg kg R . 909 pg kg dog . CN urokinase enzyme-activating a From human urine. b From culture of renal cells. Enrichment and purification occurs via combined adsorption and elution processes e. g. on BaSO4 silica gels DEAE-cellulosis ion-exchange resins e. g. Amberlite-IRC-50 . Reference s a Sobal et al. Am. J. Physiol. AJPHAP 171 768 1952 . US 2 961 382 Ortho 1960 appl. 1957 . US 2 983 647 Leavens 1961 GB-prior. 1955 . US 2 989 440 Ortho 1961 appl. 1959 . US 3 081 236 Warner-Lambert appl. . DAS 2 616 761 Hitachi Chemical appl. J-prior. . DAS 2 629 886 Asahi appl. 1976 J-prior. . DAS 2 632 212 Hitachi Chemical appl. J-prior. . b DAS 2 551 017 Abbott appl. USA-prior. . 2152 u Ursodeoxycholic acid purification White et al. Biochemistry BICHAW 5 2160 1966 . US 3 256 158 Abbott appl. . US 3 542 646 Green Cross J-prior. . DOS 2 143 815 Mochida appl. J-prior. . DOS 2 143 816 Mochida appl. J-prior. DOS 2 246 969 .
