Pharmaceutical Substances Syntheses, Patents, Applications - Part 217. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Venlafaxine V 2161 N N-dimethyl-4-methoxyphenylthioacetamide 1. 2. I N N-dimethyl-a- 1 -hydroxycyclohexyl -4-methoxyphenyl -thioacetamide III H2 Raney-Ni m ------------------ Venlafaxine Reference s a EP 112 669 American Home Products USA-prior. . b GB 2 227 743 Wyeth Brother Ltd GB-prior. . combination with opioid antagonists WO 9 609 047 Du Pont Merck Pharm. Co. USA-prior. . combination with -blockers EP687 472 Eli Lilly Co. USA-prior. . controlled release formulation WO 9 427 589 Alza Corp. USA-prior. . Formulation s tabl. 25 mg mg 50 mg 75 mg 100 mg as hydrochloride Trade Namelsj D Trevilor Wyeth GB Efexor Wyeth I Efexor Wyeth-Lederle USA Effexor Wyeth-Ayerst 2162 V Verapamil Verapamil Iproveratril ATC C08DA01 Use coronary vasodilator RN 52-53-9 MF C27H3 iN2O4 MW EINECS 200-145-1 LD50 1520 pg kg M . 130 mg kg M . 7250 pg kg R . 163 mg kg R . CN ct- 3- 2- 3 4-dimethoxyphenyl ethyl methylamino propyl -3 4-dimethoxy-ct- l-methylethyl benzeneacetonitrile monohydrochloride RN 152-11-4 MF C27H38N2O4 HCl MW EINECS 205-800-5 LD5o 5795 pg kg M . 163 mg kg M . 16 mg kg R . 108 mg kg R . 400 mg kg dog . CN o-ch3 o-ch3 H-jCs C ch3 NoNH2 2- 3 4-dimethoxyphenyl - 3- methylbutyro nitrile 1 isopropyl chloride 1 -bromo-3-chloropropone H3C y H3C ch3 . II HX 0. 11 H3c ch3 N- 2- 3 4-dimethoxy- phenyl ethyl methylamine Reference s DE 1 154 810 Knoll appl. . DE 1 158 083 Knoll appl. . US 3 261 859 Knoll D-prior. . alternative synthesis DAS 2 263 527 Teikoku Hormaone Mfg. appl. J-prior. . DAS 2 631 222 Knoll appl. . US 4 115 432 Knoll D-prior. . - -verapamil DAS 2 059 923 Knoll appl. . Formulation s amp. 5 mg 2 ml drg. 40 mg 80 mg 120 mg f. c. tabl. 40 mg 80 mg 120 mg s. r. cps. 120 mg 180 mg 240 mg s. r. .
