Table 40-2 Association between Pathobiology of Causative Agents and Clinical Features in Acute Infectious Diarrhea Pathobiolo gy/Agents bation Incu miting Vo Abd ominal Pain ever F rrhea Dia Period Toxin producers Preforme d toxin Bacillus cereus, Staphylococcus aureus, h 1–8 4+ 3– 1–2+ –1+ 0 4+, watery 3– Clostridi um perfringens h 8–24 Enterotox in Vibrio cholerae, enterotoxigenic Escherichia coli, Klebsiella pneumoniae, Aeromonas h 8–72 4+ 2– 1–2+ –1+ 0 4+, watery 3– species Enteroadhe rent Enteropat hogenic and d 1–8 1+ 0– 1–3+ –2+ 0 2+, 1– enteroadherent E. coli, Giardia watery, mushy organisms, cryptosporidiosis, helminths Cytotoxinproducers Clostridiu m difficile d 1–3 1+ 0– 3–4+ –2+ 1 3+, 1– usually watery, occasional ly bloody . | Chapter 040. Diarrhea and Constipation Part 5 Table 40-2 Association between Pathobiology of Causative Agents and Clinical Features in Acute Infectious Diarrhea Pathobiolo gy Agents Incu bation Period Vo miting Abd ominal Pain F ever Dia rrhea Toxin producers Preforme d toxin Bacillus cereus Staphylococcus aureus 1-8 h 3- 4 1-2 0 -1 3- 4 watery Clostridi um perfringens 8-24 h Enterotox in Vibrio cholerae enterotoxigenic Escherichia coli Klebsiella pneumoniae Aeromonas 8-72 h 2- 4 1-2 0 -1 3- 4 watery species Enteroadhe rent Enteropat hogenic and enteroadherent E. coli Giardia organisms cryptosporidiosis helminths 1-8 d 0- 1 1-3 0 -2 1- 2 watery mushy Cytotoxin- producers Clostridiu m difficile 1-3 d 0- 1 3-4 1 -2 1- 3 usually watery .