Etiology and Risk Factors Risk factors for the development of colorectal cancer are listed in Table 874. Table 87-4 Risk Factors for the Development of Colorectal Cancer Diet: Animal fat Hereditary syndromes (autosomal dominant inheritance) Polyposis coli Nonpolyposis syndrome (Lynch syndrome) Inflammatory bowel disease Streptococcus bovis bacteremia Ureterosigmoidostomy ? Tobacco use Diet The etiology for most cases of large-bowel cancer appears to be related to environmental factors. The disease occurs more often in upper socioeconomic populations who live in urban areas. Mortality from colorectal cancer is directly correlated with per capita consumption of calories, meat protein, and dietary fat and oil as well as elevations in the serum cholesterol concentration. | Chapter 087. Gastrointestinal Tract Cancer Part 7 Etiology and Risk Factors Risk factors for the development of colorectal cancer are listed in Table 874. Table 87-4 Risk Factors for the Development of Colorectal Cancer Diet Animal fat Hereditary syndromes autosomal dominant inheritance Polyposis coli Nonpolyposis syndrome Lynch syndrome Inflammatory bowel disease Streptococcus bovis bacteremia Ureterosigmoidostomy Tobacco use Diet The etiology for most cases of large-bowel cancer appears to be related to environmental factors. The disease occurs more often in upper socioeconomic populations who live in urban areas. Mortality from colorectal cancer is directly correlated with per capita consumption of calories meat protein and dietary fat and oil as well as elevations in the serum cholesterol concentration and mortality from coronary artery disease. Geographic variations in incidence are unrelated to genetic differences since migrant groups tend to assume the large-bowel cancer incidence rates of their adopted countries. Furthermore population groups such as Mormons and Seventh Day Adventists whose lifestyle and dietary habits differ somewhat from those of their neighbors have significantly lower-than-expected incidence and mortality rates for colorectal cancer. Colorectal cancer has increased in Japan since that nation has adopted a more western diet. At least .
