Hematologic Syndromes: Introduction The elevation of granulocyte, platelet, and eosinophil counts in most patients with myeloproliferative disorders is caused by the proliferation of the myeloid elements due to the underlying disease rather than a paraneoplastic syndrome. The paraneoplastic hematologic syndromes in patients with solid tumors are less well characterized than the endocrine syndromes because the ectopic hormone(s) or cytokines responsible have not been identified in most of these tumors (Table 96-2). The extent of the paraneoplastic syndromes parallels the course of the cancer. Table 96-2 Paraneoplastic Hematologic Syndromes Syndrome Proteins Cancers Typically Associated with Syndrome Erythrocytosis Erythropoietin Renal cancers Hepatocarcinoma Cerebellar hemangioblastomas Granulocytosis G-CSF Lung cancer GM-CSF Gastrointestinal cancer . | Chapter 096. Paraneoplastic Syndromes Endocrinologic Hematologic Part 7 Hematologic Syndromes Introduction The elevation of granulocyte platelet and eosinophil counts in most patients with myeloproliferative disorders is caused by the proliferation of the myeloid elements due to the underlying disease rather than a paraneoplastic syndrome. The paraneoplastic hematologic syndromes in patients with solid tumors are less well characterized than the endocrine syndromes because the ectopic hormone s or cytokines responsible have not been identified in most of these tumors Table 96-2 . The extent of the paraneoplastic syndromes parallels the course of the cancer. Table 96-2 Paraneoplastic Hematologic Syndromes Syndrome Proteins Cancers Typically Associated with Syndrome Erythrocytosis Erythropoietin Renal cancers Hepatocarcinoma Cerebellar hemangioblastomas Granulocytosis G-CSF Lung cancer GM-CSF Gastrointestinal cancer IL-6 Ovarian cancer Genitourinary cancer Hodgkin s disease Thrombocytosis IL-6 Lung cancer Gastrointestinal cancer Breast cancer Ovarian cancer Lymphoma Eosinophilia IL-5 Lymphoma Leukemia Lung cancer Thrombophlebitis Unknown Lung cancer Pancreatic cancer Gastrointestinal cancer Breast cancer Genitourinary cancer Ovarian cancer Prostate .
