Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 5)

Pathophysiology Bone marrow failure results from severe damage to the hematopoietic cell compartment. In aplastic anemia, replacement of the bone marrow by fat is apparent in the morphology of the biopsy specimen (Fig. 102-1) and MRI of the spine. Cells bearing the CD34 antigen, a marker of early hematopoietic cells, are greatly diminished, and in functional studies, committed and primitive progenitor cells are virtually absent; in vitro assays have suggested that the stem cell pool is reduced to ≤1% of normal in severe disease at the time of presentation. Figure 102-1 A. Normal bone marrow biopsy. B. Normal bone marrow aspirate. | Chapter 102. Aplastic Anemia Myelodysplasia and Related Bone Marrow Failure Syndromes Part 5 Pathophysiology Bone marrow failure results from severe damage to the hematopoietic cell compartment. In aplastic anemia replacement of the bone marrow by fat is apparent in the morphology of the biopsy specimen Fig. 102-1 and MRI of the spine. Cells bearing the CD34 antigen a marker of early hematopoietic cells are greatly diminished and in functional studies committed and primitive progenitor cells are virtually absent in vitro assays have suggested that the stem cell pool is reduced to 1 of normal in severe disease at the time of presentation. Figure 102-1 ra -- Sourca Faoci AS Kaspar firaunwald í Hausar L Vengo PC Jamaren Ju Ve realce J Hih im i Pnnápltl 0 Iriterni Merfclfla J Tth Edilion hittp f u a. a ce c r ma d ici n a. ce m Copyright o Th MCflWf-HUl Comptnitf. Inc- AJI rpcjrued. So urca F u i 5. Kupar CL Si aun ld 5. Haviar su. Longo PL. Jamaron jl. Lorcaltc Ji Hjínrflft r c y 17th Edition http www. cc f rmedian t. m Copyright a Ths MtSrawHHl Compañía Inc. All nght rá uad. Saun Fauci 5. kaipvr PL SM uno Id Ẹ H di 1 5t-. longç PL limatón JL Loli Iso Ji Mirnson s Prìne ỉiĩ ữi ĩĩ trrtìĩ rfod m-. . L7th Edition http Ạ UO. a-cco in Copyright ft Thí Meer -HUI CompíCil . Ipil All rightiJii i iit- - 1 ữSỉữSữữ Sourtai Flue A5. Mipar bu Ẹrinjnu l j Ẹ H uf d SL. Longq OL J in fon JL lta Ji y ĩrịsữri ĩ ft ineÿhC f ĩyị ỉtAaĩtỉíĨ . 17th Edition hbtp ovw. CC4 1 imi Copyright ft Th McQrav-HIII Compiriitt. tnc. All right .