Chapter 105. Malignancies of Lymphoid Cells (Part 5)

Table 105-5 Diseases or Exposures Associated with Increased Risk of Development of Malignant Lymphoma Inherited immunodeficiency disease Klinefelter's syndrome Chédiak-Higashi syndrome Ataxia telangiectasia syndrome Wiscott-Aldrich syndrome Common variable immunodeficiency disease Acquired immunodeficiency diseases Iatrogenic immunosuppression HIV-1 infection Acquired hypogammaglobulinemia Autoimmune disease Sjögren's syndrome Celiac sprue Rheumatoid arthritis and systemic lupus erythematosus Chemical or drug exposures Phenytoin Dioxin, phenoxyherbicides Radiation Prior chemotherapy and radiation therapy Immunology All lymphoid cells are derived from a common hematopoietic progenitor that gives rise to lymphoid, myeloid, erythroid, monocyte, and megakaryocyte lineages. . | Chapter 105. Malignancies of Lymphoid Cells Part 5 Table 105-5 Diseases or Exposures Associated with Increased Risk of Development of Malignant Lymphoma Inherited immunodeficiency disease Klinefelter s syndrome Chediak-Higashi syndrome Ataxia telangiectasia syndrome Wiscott-Aldrich syndrome Common variable immunodeficiency disease Acquired immunodeficiency diseases Iatrogenic immunosuppression HIV-1 infection Acquired hypogammaglobulinemia Autoimmune disease Sjögren s syndrome Celiac sprue Rheumatoid arthritis and systemic lupus erythematosus Chemical or drug exposures Phenytoin Dioxin phenoxyherbicides Radiation Prior chemotherapy and radiation therapy Immunology All lymphoid cells are derived from a common hematopoietic progenitor that gives rise to lymphoid myeloid erythroid monocyte and megakaryocyte lineages. Through the ordered and sequential activation of a series of transcription factors the cell first becomes committed to the lymphoid lineage and then gives rise to B and T cells. About 75 of all lymphoid leukemias and 90 of all lymphomas are of B cell origin. A cell becomes committed to B cell development when it begins to rearrange its immunoglobulin genes. The sequence of cellular changes including changes in cell-surface phenotype that characterizes normal