Chapter 105. Malignancies of Lymphoid Cells (Part 7)

Table 105-6 presents the best documented translocations and associated oncogenes for various subtypes of lymphoid malignancies. In some cases, such as the association of the t(14;18) in follicular lymphoma, the t(2;5) in anaplastic large T/null cell lymphoma, the t(8;14) in Burkitt's lymphoma, and the t(11;14) in mantle cell lymphoma, the great majority of tumors in patients with these diagnoses display these abnormalities. In other types of lymphoma where a minority of the patients have tumors expressing specific genetic abnormalities, the defects may have prognostic significance. No specific genetic abnormalities have been identified in Hodgkin's disease other than aneuploidy. Table 105-6. | Chapter 105. Malignancies of Lymphoid Cells Part 7 Table 105-6 presents the best documented translocations and associated oncogenes for various subtypes of lymphoid malignancies. In some cases such as the association of the t 14 18 in follicular lymphoma the t 2 5 in anaplastic large T null cell lymphoma the t 8 14 in Burkitt s lymphoma and the t 11 14 in mantle cell lymphoma the great majority of tumors in patients with these diagnoses display these abnormalities. In other types of lymphoma where a minority of the patients have tumors expressing specific genetic abnormalities the defects may have prognostic significance. No specific genetic abnormalities have been identified in Hodgkin s disease other than aneuploidy. Table 105-6 Cytogenetic Translocation and Associated Oncogenes Often Seen in Lymphoid Malignancies Disease Cytogenetic Abnormality Oncogene CLL small lymphocytic lymphoma t 14 15 q32 q13 MALT lymphoma t 11 18 q21 q21 API2 MALT BCL-10 Precursor B cell acute lymphoid leukemia t 9 22 q34 q11 or variant t 4 11 q21 q23 BCR ABL AF4 ALLI Precursor acute lymphoid leukemia t 9 22 t 1 19 t 17 19 BCR ABL E2A PBX HLF E2A t 5 14 HOX11L2 CTIP2 Mantle cell lymphoma t 11 14 q13 q32 BCL-1 IgH Follicular lymphoma t 14 18 q32 q21 BCL-2 IgH Diffuse large cell lymphoma t 3 - q27 - a t 17 - p13 - BCL-6 p53 Burkitt s lymphoma Burkitt s leukemia t 8 - q24 - a C-MYC CD30 Anaplastic large cell lymphoma t 2 5 p23 q35 ALK Lymphoplasmacytoid lymphoma t 9 14 p13 q32 PAX5 IgH Numerous sites of translocation may be involved with these .