Neurochemical Mechanisms in Disease P59. This volume of Advances in Neurobiology deals with the Neurochemistry of disease, with chapters covering both human diseases and animal “model” disorders. Specific diseases are covered in chapters on neurodegenerations such as Alzheimer’s and Parkinson's, on demyelinating diseases, on autism, and so on. This volume on Neurochemical Mechanisms in Disease strives to encourage more chemically based definitions of these and other diseases.