Chapter 124. Sexually Transmitted Infections: Overview and Clinical Approach (Part 19) Ulcerative Genital or Perianal Lesions: Treatment Immediate syndrome-based treatment for acute genital ulcerations (after collection of all necessary hdiagnostic specimens at the first visit) is often appropriate before all test results become available, because patients with typical initial or recurrent episodes of genital or anorectal herpes can benefit from prompt oral antiviral therapy (Chap. 172); because early treatment of sexually transmitted causes of genital ulcers decreases further transmission; and because some patients do not return for test results and treatment. The patient with nonvesicular ulcerative lesions who may not return for.