Tuberculosis Important measures for the control of tuberculosis (Chap. 158) include prompt recognition, isolation, and treatment of cases; recognition of atypical presentations (., lower-lobe infiltrates without cavitation); use of negativepressure, 100% exhaust, private isolation rooms with closed doors and 6–12 or more air changes per hour; use of N95 "respirators" (approved by the National Institute for Occupational Safety and Health) by caregivers entering isolation rooms; possible use of high-efficiency particulate air filter units and/or ultraviolet lights for disinfecting air when other engineering controls are not feasible or reliable; and follow-up skin-testing of susceptible personnel who have been exposed to infectious.