Define toxicology and toxicity. Discuss different types of toxic responses. Explain how toxicants are classified. Describe the phases of toxicosis. Explain how concomitant exposure influences toxicity. Develop an introductory understanding of toxicity testing. | Concepts in Toxicology Principles of Environmental Toxicology Instructor Gregory Möller . University of Idaho Principles of Environmental Toxicology Learning Objectives Define toxicology and toxicity. Discuss different types of toxic responses. Explain how toxicants are classified. Describe the phases of toxicosis. Explain how concomitant exposure influences toxicity. Develop an introductory understanding of toxicity testing. 2 Principles of Environmental Toxicology Toxicology The science that deal with the adverse effects of chemicals on living systems. Classifications. - Descriptive toxicology. What - Mechanistic toxicology. Why - Analytical toxicology. How much Principles of Environmental Toxicology Definition of Toxicity Toxicity The degree to which a substance can harm humans or animals. Toxicity can be acute subchronic or chronic. 3 4 Principles of Environmental Toxicology Acute Toxicity Involves harmful effects in an organism through a single or short-term exposure. Principles of Environmental Toxicology Subchronic Toxicity The ability of a toxic substance to cause effects for more than one year but less than the lifetime of the exposed organism. 5 The Death of Socrates 1787 Jacques-Louis David Metropolitan Museum of Art New York 6 1 Principles of Environmental Toxicology Chronic Toxicity The ability of a substance or mixture of substances to cause harmful effects over an extended period usually upon repeated or continuous exposure sometimes lasting for the entire life of the exposed organism. Principles of Environmental Toxicology Specialty Areas in Toxicology Target Organ System. - Neurotoxicology Genetic Toxicology Reproductive Toxicology Immunotoxicology Endocrine Toxicology. Target Species Systems. - Aquatic Toxicology Environmental Toxicology Wildlife Toxicology Veterinary Toxicology. Selected Responses. - Teratology Carcinogenesis. 7 8 Principles of Environmental Toxicology Applied Toxicology Occupational toxicology. Clinical toxicology. - Toxic
