Tham khảo tài liệu 'converging technologies for improving human performance episode 2 part 1', kỹ thuật - công nghệ, cơ khí - chế tạo máy phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Converging Technologies for Improving Human Performance pre-publication on-line version 187 Tissue Digital Automated Digital Imaging Tissue Analysis Computation Pathologist Knowledge Incorporated Here Data Available For Rich Digital Correlation With Other Datasets Including Genomic Proteomic Etc. Figure . Capture of tissue information in hyperquantitative fashion. All components of the tissue that can be made visible are located simultaneously after robotic capture of slide-based images. This step automates the analysis of tissue putting it immediately into a form that enables sharing of images and derived data. Preparation of tissue information in this way requires two steps a. automated imaging that enables location of tissue on a microscope slide and the capture of a composite image of the entire tissue or tissues on the slide b. the application of image analytic software that has been designed to automatically segregate and co-localize in Cartesian space the visible components of tissue including molecular probes if applied Tissue information captured in this way enables very precise mathematical comparison of tissues to detect change as in toxicology testing or ultimately clinical diagnostics . In each case substantial work must first be done to collect normative reference data from tissue populations of interest. More importantly when tissue information is reduced to this level of scale the data is made available for more precise correlation with other data sets in the continuum of bioinformatics in the following applications Backward correlation Sorter of genomic and proteomic data Rationale When gene or protein expression data are culled from a tissue that has undergone hyperquantitative analysis tighter correlations are possible between molecular expression patterns and tissue features whose known biological roles help to explain the mechanisms of disease and therefore may help to identify drug targets more sharply. Forward correlation Stratifier of .
