Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Gene expression neighborhoods. | J. Biol. Journal of Biology BioMed Central Minireview Gene expression neighborhoods Brian Oliver Michael Parisi and David Clark Address Laboratory of Cellular and Developmental Biology National Institute of Diabetes and Digestive and Kidney Diseases National Institutes ofHealth Bethesda MD 20892 USA. Correspondence Brian Oliver. E-mail oliver@ Published 1 July 2002 Journal of Biology 2002 1 4 The electronic version of this article is the complete one and can be found online at http content 1 1 4 2002 BioMed Central Ltd ISSN 1475-4924 Abstract The finding that neighboring eukaryotic genes are often expressed in similar patterns suggests the involvement of chromatin domains in the control of genes within a genomic neighborhood. Reductionist approaches have been a tremendous boon to understanding the regulation of transcription one of the vital steps defined by the central dogma of molecular biology. Gene-by-gene analysis has clearly shown that control regions within the DNA sequence bind protein transcription factors that up- or down-regulate the activity of promoters. But now that patterns of gene expression can be studied across the entire genome new findings suggest that as well as being controlled individually genes may also be subject to regulation according to their location within the genome. It has been clear for some time that genomic location has some impact on gene expression. For example in various species when transgenes are removed from their local environment and reinserted elsewhere in the genome the transgenes tend to work more-or-less normally but almost always show some alteration in expression due to insertion site - and sometimes the effect on expression is dramatic. That even subtle differences in gene expression can have consequences in some circumstances is also well known and is illustrated by the dramatic effects of minute concentration differences in the gradients of pattern-determining morphogens during development 1
