Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Identification of conserved regulatory elements by comparative genome analysis. | J. Biol. Journal of Biology BioMed Central Research article Open Access Identification of conserved regulatory elements by comparative genome analysis Boris Lenhard Albin Sandelin Luis Mendoza Par Engstrom Niclas Jareborg and Wyeth W Wasserman Addresses Center for Genomics and Bioinformatics Karolinska Institutet 171 77 Stockholm Sweden. Current address Serono Research and Development CH-1121 Geneva 20 Switzerland. Current address AstraZeneca Research and Development S-151 85 Sodertalje Sweden. Current address Centre for Molecular Medicine and Therapeutics University of British Columbia Vancouver BC V5Z 4H4 Canada. These authors contributed equally to this work. Correspondence Wyeth W Wasserman. E-mail wyeth@ Received 12 December 2002 Revised 21 March 2003 Accepted 8 April 2003 Published 22 May 2003 Journal of Biology 2003 2 13 The electronic version of this article is the complete one and can be found online at http content 2 2 13 2003 Lenhard et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background For genes that have been successfully delineated within the human genome sequence most regulatory sequences remain to be elucidated. The annotation and interpretation process requires additional data resources and significant improvements in computational methods for the detection of regulatory regions. One approach of growing popularity is based on the preferential conservation of functional sequences over the course of evolution by selective pressure termed phylogenetic footprinting . Mutations are more likely to be disruptive if they appear in functional sites resulting in a measurable difference in evolution rates between functional and non-functional genomic segments. Results We have devised a flexible suite of methods for the identification and .
