Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Deciphering the genetic code of morphogenesis using functional genomics. | Journal of Biology Minireview Deciphering the genetic code of morphogenesis using functional genomics Athea Vichas and Jennifer A Zallen Address Developmental Biology Program Sloan-Kettering Institute 1275 York Avenue New York NY 10065 USA. Correspondence Jennifer Zallen. Email zallenj@ Abstract A fundamental goal of developmental biology is to define the molecular mechanisms that control cell behavior during morphogenesis. A recent study in BMC Biology combines gene expression profiling bioinformatics and functional analysis to identify genes that shape the Drosophila embryo. See related research article http 1741-7007 7 61 Morphogenesis of the Drosophila embryo requires the three-dimensional organization of populations of cells with characteristic shapes and behaviors that give rise to the adult structure of the animal. Genetic screens have been instrumental in identifying genes that specify cell fate and cell behavior. Many of these include transcription factors that are expressed in precise spatial patterns and are required for distinct morphological behaviors. However the downstream pathways that translate cell fate decisions into cell shape and tissue structure are not fully understood. Current advances in genome-wide expression profiling in vivo transcription factor binding site analysis and high-throughput studies of gene-expression patterns have made it possible to identify novel genes that are expressed during morphogenetically active periods of development. Since the sequencing of the Drosophila genome large-scale expression studies using DNA microarrays have been employed in diverse ways to reveal the genetic networks that drive development. Time-course experiments using DNA microarrays have identified subsets of genes expressed at specific developmental stages throughout Drosophila embryogenesis 1-5 . The first few hours of embryogenesis are marked by active changes in cell fate cell shape and cell rearrangements that are .
