Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Teratological effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): induction of cleft palate in the ddY and C57BL/6 mouse | J. Vet. Sci. 2000 1 2 113-119 OURNAL OF Veterinary Science Teratological effect of 2 3 7 8-tetrachlorodibenzo-p-dioxin TCDD induction of cleft palate in the ddY and C57BL 6 mouse Byung-Il Yoon Tohru Inoue and Toyozo Kaneko Division of Cellular and Molecular Toxicology National Institute of Health Sciences Tokyo 158-8501 Japan 2 3 7 8-Tetrachlorodibenzo-p-dioxin TCDD a highly toxic halogenated aromatic hydrocarbon is a teratogen to induce cleft palate when exposed during the pregnancy. There are inter-strain differences in the sensitivity to cleft palate induced by TCDD and other chemicals including polychlorinated terphenyls PCTs . The C57BL 6 mouse and the ddY mouse had been shown to be different in the induction of cleft palate following the treatment of PCTs which attempts us to evaluate the TCDD-induced cleft palate in two mouse strains to understand the mechanism through which TCDD and PCTs induce cleft palate. This study evaluated the induction of cleft palate in the fetuses of ddY and C57BL 6 mice after subcutaneous treatment of TCDD on gestation day GD or oral treatment on GD . Our results clearly showed that ddY mice a susceptible strain to PCTs-induced cleft palate are resistant to the induction of cleft palate by TCDD comparably to the high susceptibility of C57BL 6 mice suggesting a different teratological mechanism between TCDD and PCTs. In addition at the low doses our study supported the concept of window effect of TCDD on around GD 12 for the induction of cleft palate in C57BL 6 and ddY mice. Key words cleft palate ddY mouse 2 3 7 8-tetrachlorod-ibenzo-p-dioxin Introduction 2 3 7 8-Tetrachlorodibenzo-p-dioxin TCDD a member of halogenated aromatic hydrocarbons is a widely spread environmental contaminant 26 . TCDD has a variety of adverse biological effects including carcinogenesis immune and hemopoietic dysfunction neuronal cell damage teratogenesis and reproductive toxicity 13 18 19 24 . The induction of cleft palate is known to .
