Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: An immunohistochemical study on the pancreatic islets cells of the Mongolian gerbils, Meriones unguiculatus | J. Vet. Sci. 2001 2 1 9-14 JOURNAL OF Veterinary Science An immunohistochemical study on the pancreatic islets cells of the Mongolian gerbils Meriones unguiculatus Sae-kwang Ku Hyeung-sik Lee 1 Ki-dae Park2 and Jae-hyun Lee2 Pharmacology Toxicology Lab. Central Research Laboratories Dong-Wha Pharm. Ind. Co. Anyang 430-017 Korea 1 Department of Biology Faculty of Natural Sciences Kyungsan University Kyungsan 712-240 Korea Department of Histology College of Veterinary Medicine Kyungpook National University Taegu 702-701 Korea In order to study the regional distribution and relative frequency of the immunoreactive endocrine cells in the pancreatic islets of the Mongolian gerbil pancreatic sections of Meriones unguiculatus were immunostained using an immunohistochemical PAP method with four types of specific antisera against insulin glucagon somatostatin and human pancreatic polypeptide PP . The pancreatic islets were subdivided into three portions central region mantle zone and peripheral region according to their composition of immunoreactive cells. Spherical to spindle shaped insulin glucagon somatostatin and PP-immu-noreactive cells were observed in this study. Insulin-immunoreactive cells were present in the central regions with high frequency and a few of these cells were also demonstrated in the mantle zones. Glucagon-immunoreactive cells were mainly restricted to the mantle zones. However rare examples were found in the peripheral regions. As for the glucagon-immunoreactive cells somatostatin-immunoreactive cells were detected in the mantle zones and peripheral regions with moderate and rare frequencies respectively. PP-immunoreactive cells were found in the mantle zones and peripheral regions with rare and moderate frequencies respectively. In the mantle and the peripheral regions cytoplasmic process of glucagon- somatostatin- and PP-immunoreactive cells were intermingled. In conclusion the regional distribution of endocrine cells in the pancreatic islets of .
