Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Immunostimulatory effects of anionic alkali mineral complex solution Barodon in porcine lymphocytes | J. Vet. Sci. 2001 2 1 15-24 JOURNAL OF Veterinary Science Immunostimulatory effects of anionic alkali mineral complex solution Barodon in porcine lymphocytes Byung Woo Yoo Soo Il Choi1 So Hyun Kim2 Soo Jin Yang2 Hye Cheong Koo2 Sang Hoon Seo Bong Kyun Park2 Han Sang Yoo2 and Yong Ho Park2 Agribrands Purina Korea Inc. Seoul 135-280 Korea . Corp. Ansung 456-880 Korea Department of Microbiology and Infectious Diseases College of Veterinary Medicine and School of Agricultural Biotechnology Seoul National University Suwon 441-744 Korea The anionic alkali mineral complex solution Barodon . Corp. Korea was evaluated for its effectiveness as a nonspecific immunostimulator in pigs. The effects of Barodon were determined by analysis of feed efficiency growth rate and phenotype of leukocyte subpopulations using monoclonal antibodies specific to porcine leukocyte differentiation antigens and flow cytometry FC . The study was focused to investigate the change in proportion of the CD4 CD8 double positive T lymphocyte subpopulation dpp which exists uniquely in pigs. In addition the mitogen-stimulated lymphoproliferative response tissue distribution in lymphoid organs and the adjuvant effect of Barodon on hog cholera vaccine efficiency were determined. The study has revealed the average daily gain rates and feed conversion rates were significantly p improved in either group of pigs fed with Barodon-spray feed Tx-1 or pigs fed with 3 Barodon-fermented feed Tx-2 in comparison with group of pigs fed with feed containing no Barodon control . The proportion of cells expressing CD4 antigen in Barodon-treated group increased from 3 weeks posttreatment and was significantly higher p than that of control at 8 weeks posttreatment. Particularly the significantly higher proportion was maintained from 8 weeks through 13 weeks posttreatment in Tx-1 group p . The proportion of cells expressing CD8 antigen was significantly higher at 3 weeks .
