Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Dose-Incidence Relationships on the Prenatal Effects of Gamma-Radiation in Mice | J. Vet. Sci. 2002 3 1 7-11 JOURNAL OF Veterinary Science Dose-Incidence Relationships on the Prenatal Effects of Gamma-Radiation in Mice Dae-won Bang Jong-hwan Lee Heon Oh Se-ra Kim Tae-hwan Kim1 Yun-sil Lee1 Cha-soo Lee2 and Sung-ho Kim College of Veterinary Medicine Chonnam National University Kwangju 500-757 Korea 1 Laboratory of Radiation Effect Korea Cancer Center Hospital Seoul 139-240 Korea College of Veterinary Medicine Kyungpook National University Taegu 702-701 Korea ABSTRACT The objective of this investigation was to evaluate dose-incidence relationships on the prenatal effects of gamma-radiation. Pregnant ICR mice were exposed on day after conception coincident with the most sensitive stage for the induction of major congenital malformations with Gy of gamma- radiations. The animals were sacrificed on day 18 of gestation and the fetuses were examined for mortality growth retardation change in head size and any other morphological abnormalities. With increasing radiation dose incidence of small head growth retarded fetuses cleft palate dilatation of cerebral ventricle and abnormalities of the extremities in live fetuses rose. The threshold doses of radiation that induced cleft palate and dilatation of cerebral ventricle and abnormal extremities were between and Gy and between and Gy respectively. Key words Radiation Malformation Dose-incidence relationship ICR mouse INTRODUCTION Irradiation of mammalian embryos can produce a spectrum of morphological changes ranging from temporary stunting of growth to severe organ defects and death 2 . During the period of major organogenesis mammalian embryos are highly susceptible to radiation-induced gross anatomic abnormalities this period spans 7 to 12 days post-coitus . in mice corresponding to about 14 to 50 days in humans 5 . The induced abnormalities depend on the organs undergoing differentiation at the time of the irradiation the stage of differentiation and the radiation dose
