Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Immunohistochemical Localization of Nerve Growth Factor,Glial Fibrillary Acidic Protein and Ciliary Neurotrophic Factor in Mesencephalon, Rhombencephalon, and Spinal Cord of Developing Mongolian Gerbil | J. Vet. Sci. 2002 3 3 239-245 JOURNAL OF Veterinary Science Immunohistochemical Localization of Nerve Growth Factor Glial Fibrillary Acidic Protein and Ciliary Neurotrophic Factor in Mesencephalon Rhombencephalon and Spinal Cord of Developing Mongolian Gerbil Il-Kwon Park Kyoug-Youl Lee Chi-Won Song Hyo-Jung Kwon Mi-Sun Park Mi-Young Lee Keun-Jwa Lee1 2 3 4 5 6 Young-Gil Jeong Chul-Ho Lee Kwon-Soo Ha Man-Hee Rhee Kang-Yi Lee and Moo-Kang Kim College of Veterinary Medicine Chungnam National University lChungnam Veterinary Service Laboratory College of Medicine Konyang University 3Korean Research Institute of bioscience and biotechnology KRIBB 4College of Medicine Kangwon National University department of Cell Biology Physiology College of Medicine Washington University 6College of Oriental Medicine Daejeon University Received April 10 2002 Accepted August 7 2002 Abstract The distribution of the nerve growth factor NGF the glial fibrillary acidic protein GFAP and the ciliary neurotrohic factor CNTF was performed in coronal sections of the mesencephalon rhombencephalon and spinal cord in the developing Mongolian gerbils. Generally NGF specifically recognizes neurons with the NGF receptor whereas GFAP does the glia and CNTF does the motor neurons. The receptor expression was examined separately in gerbils between embryonic days 15 E15 and postnatal weeks 3 PNW 3 . The NGF-IR was first observed in the spinal cord at E21 which might be related to the maturation. The GFAP reactivity was peaked at the postnatal days 2 PND2 while the highest CNTF-reaction was expressed at PNW 2. The GFAP stains were observed in the aqueduct and the spinal cord which appeared to project laterally at E19. The CNTF was observed only after the birth and found in both the neurons and neuroglia of the substantia nigra mesencephalon cerebellum and the spinal cord from PND1 to PNW3. These results suggest that NGF GFAP and CNTF are important for the development of the neurons and the neuroglia in .
