Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Studies on the effects of biomedicinal agents on serum concentration of Ca2+, P and ALP activity in osteoporosis-induced rats | J. Vet Sci. 2003 4 2 151-154 Veterinary Science Studies Ml the Effects of Biomedicinal Agents Ml Serum Concentration of Ca2 p and ALP Activity in Osteoporosis-Induced Rats Sang-keun Kim Myung-hun Lee1 and Man-hee Rhee2 College of Veterinary Medicine Chungnam National University 220 Gungdong Yusong-Gu Daejeon 305-764 Korea National Veterinary Research and Quarantine Service Anyang 430-824 Korea 2College of Veterinary Medicine Kyungpook National University Daegu 702-701 Korea Received April 3 2003 Accepted July 9 2003 Abstract The present study was carried out to investigate the effects of biomedicinal agents on Ca2 p and alkaline phosphatase ALP levels in ovariectomized rats. Rats were ovariectomized bilaterally and were fed up with Ca2 and P-free diet during 8 10 weeks to induce osteoporosis. Osteoporosis was determined by the extent of bone density and by lowering the concentrations of serum Ca2 p and ALP activity every week. Rats in antler safflower ipriflavon or coadminisrated with estrogen groups were administrated with feed supplement for 5 weeks to elucidate the protective and therapeutic effects against osteoporosis. The bone tissue was examined with electron microscope to determine the effects of each treatment on osteoporosis. 1. The levels of serum Ca2 and p in osteoporosis-induced rats administrated with antler ipriflavon and estrogen groups were little higher than those of control rats. However the levels of serum Ca and p in ovariectomized rats were significantly higher than those of control group p . 2. The activities of serum ALP in osteoporosis-induced rats administrated with antler extract safflower ipriflavon or co-admistrated with estrogen were little increased in comparing with those of control group but were significantly decreased in with combination of estrogen for 5 weeks. However The connections were interrupted and the bone matrix was destroyed in the osteoporosis-induced rats. 3. The inter-trabecular connections were examined under .
